The key difference between Paget’s Disease and Eczema is that the Paget’s disease is a focal disorder of bone remodeling, and eczema is an inflammatory condition of the skin characterized by groups of vesicular lesions with a variable degree of exudates and scaling.
Paget’s disease occurs because of the mutations in certain genes such as nuclear factor kappa B, sequestosome p62, and osteoprotegerin. On the other hand, eczema occurs as a result of the hypersensitivity reactions mounted against different allergens. This difference in pathogenesis is the principal difference between the two diseases.